ABSTRACT
Bone infection is an osteal disorder with bone damage resulting from infection of bone marrow，cortex，periosteum and surrounding tissues，characterized by a high incidence and severe symptoms. The treatment is often complicated and prolonged. Regardless of the method used，the goal is to reduce bone defect caused by infection，control infection，rebuild impaired tissues，and promote bone healing，so as to restore bone homeostasis. Starting from bone homeostasis，the authors review the research progress in the commonly used drugs and molecular mechanisms that affect bone formation-related pathways caused by bone infection，activate bone resorption-related mechanisms，and regulate bone homeostasis，in order to provide a theoretical basis for reducing bone defect caused by bone infection and promoting bone healing.